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Surgery success rates are generally good for pain relief (70 to 90% improvement in leg pain symptoms), but come with risks: infection, nerve damage, disc reherniation (5 to 15% recurrence rate after microdiscectomy), and adjacent segment disease with fusion (20 to 30% develop problems within 10 years)
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Conclusions GLP-1R analogs represent a promising frontier in the treatment of various pain disorders
Experimental autoimmune encephalitis (EAE) is a well-established animal model that accurately mimics the CNS demyelinating lesions and T-cell responses observed in MS [260]
overall, one showed a more beneficial profile 52 , while the other three did not find any consistently positive effect 53,54,55
