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Topical peptides are useful for certain applications (GHK-Cu copper peptide has reasonable evidence for topical activity), but for the major therapeutic peptides growth hormone secretagogues, BPC-157, Epithalon systemic delivery is required to produce the effects seen in the research literature

However, the exact functional significance of aberrantly glycosylated IGF-1R is not clear

Injury severity and duration: Longer-standing issues require longer treatment

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In such cases, there is no need to treat it, and it is often discovered by chance during a medical evaluation for another problem