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Users with longer treatment duration (6+ months) typically stabilize at plateau maintaining 40-60% of peak improvements, while short-term users (under 3 months) often continue gradual decline approaching pre-treatment baseline by month 4-6

Industry-funded trials account for more than two-thirds of Phase 3 trials (with much of the balance supported by the NIH, explaining the noisy data for other federal agency funding) and greater than 50 percent of all clinical trials (with NIH funding supporting 1020 percent of all trials since 2008)