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Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

Here we defined a signature of 59 genes and two metabolites (GSH and NADP) that is robustly associated with NRF2 dependency across an extensive panel of cancer cell lines

Se-dependent GPX modules are encoded in a number of RNA viruses, including HIV-1, HCV, Coxsackies virus B3, and HIV-2 virus

70 BCKDK inhibitors are also effective in attenuating insulin resistance in mouse models of obesity, and the development of a new generation of more powerful BCKDK inhibitors is important for diseases that require inhibition of BCAA catabolism

The bonus is it might also help associated issues like oxidative stress load and even anxiety (since oxidative stress can fuel anxiety)