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Combined with a low-fat diet, 5-Amino-1MQ treatment rapidly normalized body weight and adiposity to levels matching age-matched lean animals, an outcome that diet alone could not achieve in the same timeframe

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Mechanistically, emerging evidence supports the significance of heme, a red blood cell metabolite, in the microenvironment in promoting NRF2-driven macrophage differentiation into immunosuppressive M2 phenotypes

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