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A marked sex difference was observed in rats, with a ten-fold greater induction of CYP3A in females than in males and a four-fold greater induction of CYP4A in males than in females

25 However, some patients experience increased anxiety related to appetite suppression and rapid weight loss

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In vitro hepatic models suggested that flavonoids and sulfur-containing compounds in garlic supplements might interfere with the activity of efflux drug transporters of the ATP-binding cassette (ABC) family, including P-glycoprotein, multidrug resistance protein (MRP), and breast cancer-resistance protein (BCRP), which function as ATP-dependent efflux pumps that actively regulate the excretion of a number of drugs limiting their systemic bioavailability