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Ethics statement The studies involving humans were approved by Ethical Committees of the Instituto de Biologa y Medicina Experimental, Buenos Aires (Ref: CE 001/April 2019)

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Studies suggest that glutathione levels naturally decrease with age, along with exposure to stress, UV radiation, tobacco, alcohol, and environmental toxins like pollution

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To ascertain the role of DMF in activating the TSS pathway, we asked whether DMF could induce the expression of factors suppressed by hemin