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306,308,314,315,316 NAD + contributes to the bactericidal activity Bacterial infection induces rapid production of intracellular ROS either by NOXs or mitochondria that are, in turn, crucially required by macrophages to clear bacteria

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Insulin resistance is the most potent pathogenic potentiator, which promotes a pro-inflammatory state, with increased lipolysis, de-novo lipogenesis and free-fatty acid flux