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ROS inhibit endothelial nitric oxide synthase (eNOS), reducing NO production and compromising vasodilation

This area requires further extensive investigation

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Another prospective study demonstrated that the same reduced functional variants of OCT1 (M420del, R61C, G465R, and G401S) were linked to trough concentrations of metformin and progress in HbA1c post 6 months of metformin treatment in a group of 151 diabetic patients in South Danish cohort (Christensen et al., 2011)

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