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Community oral doses (50-150 mg daily) are based on allometric scaling from mouse studies, oral bioavailability data, and several years of community trial and error

For example, non-invasive positive pressure ventilation is often used to help patients with ALS breathe, especially at night (Mustfa 2006

doi: 10.1016/j.ccc.2022.07.006 [PubMed] 36807987 Trinka E

Children with various forms of organic acidaemia have carnitine requirements that exceed their dietary intake and biosynthetic capability, in order to permit excretion of accumulating organic acids