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The acute side effects that EMS may be called for are generally gastrointestinal in nature

A further dimension emerged in May 2026, when the ATTAIN-MAINTAIN trial, published in Nature Medicine , found that patients who switched to orforglipron after achieving substantial weight loss on injectable GLP-1s maintained approximately 7580% of that weight reduction

Table S2: Cohorts, patient count, and PSM components before and after matching

FRAX is available in print and online and does not require a DEXA scan, making it useful for initial risk stratification in clinical settings where imaging may not be immediately accessible

This happens because medication does not address: Stress and emotional eating Poor sleep Low muscle mass Inadequate strength training For peri-menopausal women, repeated cycles of weight loss and regain can worsen bone loss and muscle decline , increasing long-term injury risk