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"While GLP-1 medications affect gastrointestinal tract motility, their quantified impact may not be as significant as previously assumed, said corresponding author, Dr Walter Chan, director of the Center of Gastrointestinal Motility and a physician in the Brigham's Division of Gastroenterology, Hepatology and Endoscopy

The plasmid DNA encapsulated by LNPs demonstrated optimal characteristics for liver targeting, including particle size of approximately 100 nm, low polydispersity (approximately 0.2), neutral surface charges, and high DNA encapsulation efficiency (Supplementary Table 4) 25

The magnitude of effect seen in those clinical trials is substantially larger than what has been shown for most prior weight loss pharmacotherapies

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Researchers may uncover novel insights that may advance our understanding of complex physiological processes by further characterizing the interactions and impacts of Fragment 176-191, Mod GRF 1-29, and Ipamorelin