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In addition, serum insulin levels in insulin-resistant patients with HS correlated with increased lesional skin mTOR gene expression at 30 ( r =.80) and 60 ( r =1.00) minutes, and mTOR was found to be upregulated in lesional and extralesional skin in patients with HS compared to healthy controls ( P 30) and melanoma stages 1 and 2 groups but did not reach statistical significance