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Dev Neurobiol

To enhance the oral absorbtion of the drug, metformin prodrugs were developed with improved permeability across the lipid membrane 120

Further research is needed to develop strategies to stimulate glycolysis appropriately, ensuring that its byproducts are metabolized without accumulating in neurons, or to find ways to enhance glycolysis while clearing its harmful byproducts

Renal Outcomes: Kidney Injury Risk Tirzepatide may protect renal function chronically, but acute kidney injury can arise from severe vomiting or diarrhea that causes dehydration