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A catabolic state increases ammonia production due to protein degradation thereby limiting the effect of increased excretion of ammonia by forced diuresis
Structurally modified to reduce binding to IGF-binding proteins, IGF-1 LR3 may remain bioactive significantly longer than unmodified IGF-1 under experimental conditions, allowing for sustained receptor engagement and downstream pathway analysis
Biomedicine & Pharmacotherapy 2018;97, 928940, doi: Yousefzadeh, M
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