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What happened: Danish drugmaker Novo Nordisk launched the worlds first GLP-1 weight-loss pill yesterday in the U.S., beating its rival Eli Lilly to whats expected to be the next frontier of the lucrative obesity drug market

However, important contraindications exist: personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2, severe pancreatitis history, and end-stage renal disease require careful clinical assessment

The rise (and rise) of GLP-1s GLP-1s (short for glucagon-like peptide-1 receptor agonists) are a class of medications originally developed for people with type 2 diabetes

Possible side effects are mild and may include slight redness or tenderness at the injection site, which typically resolves within a few hours

But sometimes, constipation can get in the way, leaving you uncomfortable and frustrated