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Late in 2023 the Food and Drug Administration approved Zepbound (tirzepatide) injection for chronic weight management in adults with obesity and a BMI of 30 or over with at least one weight-related condition (such as high blood pressure, type 2 diabetes or high cholesterol) for use, in addition to a reduced calorie diet and increased physical activity

Safety monitoring for combinations: While individual peptides generally safe, combinations theoretically increase side effect risks

Patients should watch for an official FDA notice or change to the regulation rather than relying on summaries that use approved, unbanned, or legalized as shorthand

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This receptor was originally identified as R eceptor for A dvanced G lycation E nd-products (RAGE)