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The median total dose (including all administrations from pre-surgical PK and loading doses to post-hospital follow up) was 629 IU/kg (range: 464 1,457 IU/kg) for major orthopedic surgeries, 489 IU/kg (range: 296 738 IU/kg) for major non-orthopedic surgeries

Adverse events are usually limited to injection-site reactions: transient soreness, redness, occasional bruising

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