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If you take diphenhydramine, cetirizine, or similar medications regularly, they may be contributing to fatigue that gets attributed to tirzepatide
While semaglutide mimics one hunger-regulating hormone, GLP-1, tirzepatide mimics two hormones, GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)
The medication, with a half-life of about 3.5 hours, is administered daily via injection, often before bedtime, to mimic natural growth hormone release [11]