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Edizer and colleagues have also observed reduced immunohistochemical reactivity to collagen III and V in the treated nerve as well as minimal immune infiltration and normal structure of axons and neurofilaments (Tuna Edizer et al., 2019)

it is also about consistency and formulation

Drug Deliv 24(1):19091926

Effectiveness: How Alternatives Compare Understanding how different alternatives compare in real-world effectiveness helps set appropriate expectations