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Incompatible ingredients requiring separation include vitamin C (use morning versus evening rather than together), strong exfoliating acids (alternate nights rather than same routine), and retinoids (can be combined carefully but may increase irritation, alternating nights often works better)

The "stress" could be from infection, chronic stress, trauma, and other insults we discussed above

Larger doses do not make up for missed days

However, there are still several unresolved questions regarding their mechanism of action, interactions with other proteins, and their influence on plant development and stress-responsive signaling