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p62 is degraded through autophagic processes, along with the cargo it delivers to the autophagosome

This is essential for the accurate characterisation of the drug's safety profile and for the protection of all trial participants

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In a word, the mechanism of the negative effect of high Se intake on the antioxidant system of aquatic animals is still unclear

However, since the same inhibitors had already effectively reduced the ROS load in MUN placentas, it would be expected that thioredoxin upregulation may not occur