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68 weeks both arms STEP 1 (NEJM 2021) vs STEP 2 (Lancet 2021)

Primary causes of muscle-related discomfort include: Injection site reactions, affecting 0.2% to 1.2% of users [7] Dehydration from digestive side effects Rapid weight loss leading to muscle mass changes Exercise-related soreness from new fitness routines A particularly noteworthy concern is the potential for sarcopenia, characterized by the loss of muscle mass, strength, and function

Both are usually taken once a week through injection

Plans are HSA and FSA eligible, and subject to supply availability

Table 5 Extent of change in renal function variables with respect to baseline at 6 and 12 months after starting semaglutide treatment