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Coenzyme found in all lifeforms, that is important for metabolism as an energy molecule.

It generates reactive oxygen species (ROS) that trigger the dysregulation of essential cellular functions, ultimately affecting cellular health and homeostasis

10.1016/s0891-5849(01)00513-5 10.1016/s0891-5849(01)00513-5 [DOI] [PubMed] [Google Scholar] Turrens JF, Boveris A (1980) Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

Abstract Ferroptosis is a newly identified programmed cell death induced by iron-driven lipid peroxidation and implicated as a potential approach for tumor treatment