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[2] [3] This includes oral hormonal contraceptives, where women should be advised to use a non-oral contraceptive method or add a barrier method for 4 weeks after initiation and each dose escalation

This initiates a targeted signaling cascade that creates a pulsatile release of growth hormone

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That standardization lets investigators quantify the repair output total collagen, hydroxyproline as a collagen marker, glycosaminoglycan content, DNA content as a proxy for cell number and compare a treated chamber directly against a control chamber under matched conditions