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Because cysteine is relatively scarce in the standard diet, its availability often acts as the bottleneck for glutathione production

found that these two vectors were highly expressed in myocardial mitochondria and showed that inhibition of DIC and OGC increased mitochondrial ROS and GSH depletion, exacerbating ferroptosis in the myocardium [60]

Adverse Reactions/Side Effects Clinical Trials Experience Transient nausea and vomiting have been observed

Research confirms that vitamin C helps restore glutathione to its reduced, active form

Retrospective case series of paediatric patients referred to national poisons centres also report a lower rate of liver injury and hepatotoxicity in children compared with adults following single acute overdose [52,53,54,55]