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In 2021, the FDA approved Novo Nordisk's Wegovy, a slight reformulation of Ozempic designed specifically for weight loss, which drove a huge spike in public awareness of GLP-1 agonists

GLP-1 medications like semaglutide and tirzepatide have demonstrated weight loss results averaging 15-22% of body weight in clinical trials

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The combined treatment of sCT and liraglutide, especially when administered in a stepwise manner, produced greater body weight loss, reduced adiposity and decreased plasma leptin levels compared to individual monotherapies and vehicle in DIO rats

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