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Lactylation of NLRP3 at lysine 245 enhances its stability, triggering cardiomyocyte pyroptosis and promoting myocardial ischemiareperfusion (I/R) injury
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Ice crystals form within the solution, physically shearing peptide bonds and denaturing the protein
A fully frozen gel pack placed directly against a vial can freeze the medication, which is equally destructive as overheating
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