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In addition, SHMT2 depletion has been shown to induce mitochondrial respiratory chain deficiency by reducing basal respiration and respiratory capacity, decreasing NAD + /NADH ratios, and lowering the expression levels of respiratory complex I, IV, and V proteins [93]

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doi: 10.1038/s41598-024-58618-2 78 GuinSRuYAgarwalNLewCROwensCComiGPet al