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What Regulatory Bodies and Experts Say About GLP-1 Plus Phentermine The American Academy of Clinical Endocrinologists (AACE) and The Obesity Society have not issued formal position statements endorsing GLP-1 combined with phentermine, reflecting clinical equipoise and safety uncertainty

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Compared with placebo, GLP-1RAs treatment in T2DM patients significantly reduced the risk of death from cardiovascular disease and fatal/non-fatal stroke in cardiovascular outcome trials (Qin and Song, 2022)