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Concomitant administration of glutathione precursor N-acetylcysteine (NAC) has been shown to reduce cisplatin-induced nephrotoxicity and as a standard treatment for paracetamol overdose by replenishing depleted GSH
756 Advances in materials technologies such as organ-on-a-chip and 3D bioprinting could be important for this purpose
Bull Exp Biol Med 2002;133:6146
On the one hand, Akkermansia muciniphila enhances the junction strength between intestinal epithelial cells by regulating the expression of tight junction proteins, such as ZO-1, Occludin, and Claudin-1, to attempt to repair the disrupted intestinal barrier (Liu et al., 2023)
This HO-CO pathway has been recently proposed to be involved in the defence against oxidative stress and the deleterious effects of NO, since it removes the cytotoxic free heme, and produces some molecules with antioxidant and anti-inflammatory effects, such as biliverdin and CO [8, 3840]
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