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In fibrotic remodeling hearts, regardless of the fibrosis etiology, collagen I and III synthesis is markedly upregulated 41

Image source: Source A significant hurdle in creating oral GLP-1 receptor agonists is ensuring the medication remains stable in the stomachs harsh environment, filled with strong acids that can break down the medicine before it reaches the intestines

The dose may be increased by 500 mg per day on a weekly basis, up to a maximum of 2000 mg daily (administered as 1000 mg twice daily), or less, as limited by the highest tolerated and effective dose, especially in younger children (Table 1) [42]

For reconstitution, a larger 3mL syringe is often easiest for handling volumes of 1-2mL