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To achieve the enrollment target for the substudy (approximately 100 participants), the main study was overenrolled ( n = 338 versus planned n = 300)

Wolpin BM, Bao Y, Qian ZR, Wu C, Kraft P, Ogino S,

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The TRIUMPH-4 trial reported that cardiovascular risk markers were reduced, including non-HDL cholesterol, triglycerides, and high-sensitivity C-reactive protein