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Moreover, IL-1 signaling plays a vital role in the pathogenesis of HF as it regulates the inflammatory process and increases the activity of matrix metalloproteinases (proteolytic enzymes that break down various proteins in the extracellular matrix)

Because chronic stress often leads to disturbed sleep (irregular sleep patterns, awakenings, poor sleep quality) and emotional and psychological responses, anything that helps the nervous system calm down and reset can support the entire sleep-recovery-stress loop

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