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The N-terminal region of BNIP3 contains a LIR motif surrounded by serine at position 17 (Ser17) and serine at position 24 (Ser24), and the binding of BNIP3 to GABARAPL2 and LC3B is closely related to the phosphorylation of Ser17 and Ser24 [65]

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They reduce acute exacerbation risk and improve long-term prognosis

In DMM-induced OA models, SM04690@ApoF reduces OARSI scores by 40%, preserves cartilage structure, and promotes proteoglycan deposition

Injection Site Reactions More common with IGF-1 DES , which is injected directly into the muscle: Localized redness or swelling Muscle soreness Temporary inflammation These reactions usually resolve within a day