Similarly, the absence of MT1/2 significantly exacerbates renal oxidative damage and inflammation induced by intermittent hypoxia, with the Nrf2 signaling pathway implicated
Studies indicate that HIF-2, upon stimulation by inflammatory factors such as IL-1, leads to a decrease in GSH levels, thereby increasing chondrocytes sensitivity to lipid peroxidation and ferroptosis
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In this experiment, the high protein diet can promote intestinal secretion of GLP-1, improve FGF21 resistance, upregulate LKB1 to activate the AMPK pathway, downregulate the expression of SERBP-1c mRNA and protein in the liver, and ultimately inhibit liver lipid synthesis [50]
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