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Once-weekly administration of a long-acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non-human primates

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Future work will therefore focus on combining XChem hit matter with the main NMR hit series through structure-guided merging and linking of fragments to design more potent, drug-like, and cell-permeable tool compounds