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The 1998 Raun discovery paper (PMID 9849822) anchors this stream, with potency comparable to GHRP-6 and selectivity against ACTH/cortisol elevation

It is synthesized primarily in the cytosol of mammalian cells, with the highest concentrations found in the liver

Kremennaya MA, Soldatov MA, Podkovyrina YS, Dadasheva IA, Soldatov AV

Importantly, treatment of a triple-negative breast cancer mouse model with the NAD + precursor nicotinamide mononucleotide (NMN) reduced tumour growth and did not impair the efficacy of chemotherapy drugs in vivo or in diverse cancer cell lines

TRPV1, transient receptor potential cation channel subfamily V member 1