Common side effects include nausea, diarrhea, and constipation, which often diminish as the body adjusts to the medication
Wegovy and other GLP-1 weight loss medications have become widely used, but federal lawsuits now allege that some patients were not adequately warned about serious gastrointestinal and vision-related injuries
Additionally, preclinical research indicates potential neuroprotective effects through reduction of oxidative stress and protection of nerve cells against various forms of damage
For example, the enzymatic activity of poly (ADP-ribose) polymerase (PARP)1, a representative NAD + degrading enzyme, increases in various organs such as the liver, kidney, skeletal muscle, lung, and heart owing to the accumulation of DNA damage associated with aging and HFD-induced obesity and correlates with age- and obesity-related changes in NAD + levels [46,56,57,58]
doi: 10.1186/s12970-017-0184-9, 76