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Most of these studies identify attenuation of insulin resistance as the primary mechanism of action [72]

The SURMOUNT-1 trial with tirzepatide showed a somewhat better ratio, with lean mass reduced by 5.67 kg (10.9 percent from baseline) alongside a total weight reduction of 22.1 kg (20.9 percent), putting the fraction of weight lost from lean mass at 25.7 percent

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With GLP-1 usage expanding rapidly amid Indias mounting metabolic disease burden, the advisory signals CDSCOs intent to draw clearer boundaries around ethical promotion and prevent consumer manipulation, particularly of vulnerable populations