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Male infertility: etiological factors

thus, this drug acts as a GHR antagonist in mice

Current challenges in NADs development Unlike traditional small molecules and antibody drugs that exert their pharmacological effects on proteins, most NADs directly regulate gene expression, offering a broader range of targets

However, caution may be warranted regarding potential nephrotoxicity during long-term use, as a slight increase in urea and creatinine levels was reported in rats receiving the water leaf extract orally for 60 days (397)

Enhance the expression of osteogenic markers Osteocalcin (OC): Upregulates OC mRNA and protein expression by 20% -30%