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This large cohort of lower financial return programs demands scrutiny to confirm that each serves a high unmet need and is differentiated or first in class, justifying its place in an increasingly resource-constrained portfolio

Nutrient signals like glucose and fats, as well as hormonal signals including glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), Peptide YY (PYY), ghrelin, cholecystokinin (CCK), and bile acids, enter the central nervous system (CNS) through the bloodstream or the vagus nerve

10.1182/blood.v92.4.1191.416k15_1191_1198 [DOI] [PubMed] [Google Scholar] La Torre G., Calzoni L., Colamesta V., Guzzo A

That means personalizing decisions and using low-cost monitoring when available