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Ascorbic acid is a cofactor for many enzyme-catalyzed reactions such as maintaining of connective and vascular tissue's integrity, enhancing the collagen biosynthesis and iron absorption, modulating the leukocyte and hematopoiesis functioning, neuroprotection, and hydroxylation of lysine and proline (May and Harrison, 2013

It can improve insulin sensitivity, reduce fasting blood sugar levels, and lead to favorable changes in lipid profiles

Chronic hyperglycemia drives mitochondrial overstimulation, leading to excessive electron leakage at complexes I and III of the ETC, producing superoxide anions (O 2 - )

Sackesen C, Ercan H, Dizdar E, Soyer O, Gumus P, et al: A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma

Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate anti-tuberculosis chemotherapy