Avoid reconstitution in buffers containing strong chelators (EDTA, EGTA) or reducing agents (DTT, -mercaptoethanol, TCEP)
Individuals with cardiovascular risk factors such as hypertension, high cholesterol, or history of heart attack or bypass surgery are at increased risk of having an NSAID-related cardiovascular event (Conaghan 2012)
Laminotomy removes only a portion of the lamina, carving a window just large enough to relieve pressure in one specific spot

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Birth defects which have been documented following isotretinoin exposure include abnormalities of the face, eyes, ears, skull, central nervous system, cardiovascular system and thymus and parathyroid glands