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Strangfeld A, Listing J, Herzer P, et al

NNMT is an enzyme that methylates nicotinamide, consuming S-adenosylmethionine (SAM) in the process

For example, people who have pernicious anemia, a condition in which they cannot make intrinsic factor which is needed for B12 absorption are not able to use vitamin B12 from foods or dietary supplements

It appears to accelerate the healing of various tissues including tendons, ligaments, muscles, and the GI tract

Although very rare, serious side effects have been reported including eye abnormalities, pancreatitis, hepatitis, ulcerative colitis, Crohns disease, anaphylactic shock, Stevens-Johnson syndrome, and suicide attempts