Precautions Diabetic Ketoacidosis : Semaglutide should not be used in individuals with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis
Moreover, semaglutide and other GLP-1 receptor agonists have been shown to reduce the risk of adverse cardiovascular events in patients with diabetes, but they had not been tested for this purpose in patients with no history of diabetes
Medical supervision also reduces the likelihood of improper use, such as incorrect injection sites, missed doses, or incorrect dosing
Furthermore, SSTRs, particularly SSTR5, are highly expressed in intestinal L-cells that secrete glucagon-like peptide-1 (GLP-1) and K-cells that secrete glucose-dependent insulinotropic polypeptide (GIP)
While studies sponsored by leading pharmaceutical companies suggest a much higher likelihood of weight regain, those studies are not reflective of the average person with obesity