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While a vast body of evidence demonstrates a correlation between elevated pro-inflammatory cytokines (e.g., IL-6, TNF-) and depressive severity in IBD patients, the causal impact of pharmacological neutralization of these mediators is still being delineated through rigorous clinical trials (Luo et al., 2025)

Phytomedicine, 129 , Article 155637

2 Gastroenterology (2012) Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failureThe pivotal STEPS trial (PMID 22982184)

IGF-1 Long[R3] is significantly more potent than IGF-1 in vitro and in vivo