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However, even more potent GLP-1 RAs have limitations, including gastrointestinal adverse events and loss of lean mass [7]

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When prescribed, clinicians typically consider: BMI requirements: Adults with obesity (typically BMI of 30 or higher), or overweight (BMI of 27 or higher) with at least one weight-related health condition like high blood pressure, type 2 diabetes, or high cholesterol Medical evaluation: A clinician reviews your complete health history before prescribing Certain medical conditions may make oral semaglutide inappropriate

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