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Animals were acclimatized for one week before experimentation under controlled conditions (22 C, 12-h light/dark cycle) with food and water available ad libitum

Genetic Predispositions in Antioxidant and Detoxification Pathways Genetic variants affect enzyme activity in glutathione synthesis, recycling, and utilization

On the contrary, GPX4 activation suppressed ferroptosis and inflammatory responses via blunting arachidonic acid (AA) oxidation and NF-B pathway activation, accompanying by decreased ROS generation [57]

ATP assay ATP was measured as previously described 6,15 and briefly described here

It is well-established that disruption of the hepatic fatty acid oxidation, lipogenesis, and insulin signaling pathways contributes to hepatic steatosis