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Elevated insulin causes an increase of free serum IGF-1, nevertheless, as resistance to insulin progresses, the liver becomes insensitive to insulin-mediated suppression of IGFBP-1 [254, 256]

Adequate B vitamin availability supports: Normal digestive enzyme activity Maintenance and repair of the intestinal lining Neural signaling involved in GI motility Effective nutrient absorption This makes B-complex particularly relevant for individuals with altered intake, impaired absorption, or increased gastrointestinal stress

[PubMed: 22131550] 40

improves insulin sensitivity